Product Information

 

How NUFLOR GOLD Works: Fast-acting with a Broad Spectrum

NUFLOR GOLD Microbiology

  • Active against many Gram-negative and Gram-positive bacteria isolated from domestic animals.
  • Bacteriostatic against Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis.
  • Exhibits bactericidal activity against strains of M. haemolytica and H. somni.

The table below presents NUFLOR GOLD Minimum Inhibitory Concentration (MIC) data on the three pathogens for which data is available.

Florfenicol MIC1 Values of Indicated Pathogens Isolated from Cattle with Naturally Occurring BRD
Indicated
Pathogens
Year of
Isolation
No. of
Isolates
MIC502
µg/mL
MIC902
µg/mL
MIC range
µg/mL
Mannheimia haemolytica 2006 158 1.0 1.0 0.5 to 32
Pasteurella multocida 2006 103 0.5 0.5 ≤0.125 to 16
Histophilus somni 2006 85 ≤0.125 ≤0.125 ≤0.125 to 0.25

1The correlation between in vitro susceptibility data and clinical effectiveness is unknown.
2The MIC to encompass 50% and 90% of the isolates, respectively.

NUFLOR GOLD Clinical Pharmacology

NUFLOR GOLD is fast-acting, rapidly exceeding MICs, as shown in the graph below.

Mean Florfenicol Plasma Concentration versus Time Following a Single Subcutaneous Injection of NUFLOR GOLD at a Dose Rate of 40 mg Florfenicol per kg Body Weight in Feeder Calves (Mean of 24 Animals)

Florfenicol plasma concentrations were 2 µg/mL within two hours of injection.

Dosage, Administration, Withdrawal

  • A single subcutaneous (SQ) dose at a rate of 6 mL/100 lb.
  • To be administered in the neck only, not to exceed 15 mL per injection site.
  • Do not use in female dairy cattle 20 months of age or older, as use in lactating dairy cattle may cause milk residues.
  • Not for use in cattle of breeding age. Do not use for calves intended to be processed for veal.
  • Animals intended for human consumption must not be slaughtered within 44 days of treatment.
 
 

The Importance of
Mycoplasma bovis

People who chose Nuflor Mycoplasma bovis is now being recognized for its dual role in BRD: causing infection and accelerating infection by other bacteria.
Learn More

Causes and Signs of BRD